One of my only drawbacks to installing Vista 64 was that I have an iPhone, and Vista 64 was not supported by iTunes.  I had found some work arounds to get it working on Vista 64 with some creative work-arounds. It's funny because basically the day that I installed Vista 64 was also the day Apple released the 1.1.3 firmware for the iPhone, and coincidentally, 64 bit support for iTunes!

Yep, head over to Apple and get your 64 bit iTunes!